质量标准:【产品介绍】Akt1/PKBa is a Ser/Thr protein kinase
whose kinase activity plays a key role in various
cellular functions, including apoptosis, glycogen
synthesis, a n d cell growth . Akt1/PKBa is activated
by various growth a n d survival fact o r s (1). Phosph
o r ylation on Thr308, Ser473 a n d Tyr474 is required
f o r full activity. Akt1/PKBa inhibits apoptosis by
phosph o r ylating a n d inactivating several
targets, including caspase-9 (2). Akt1/PKBa
regulates glycogen synthesis by phosph o r ylating
a n d inactivating glycogen synthase kinase-3a
a n d b (3,4). Three mammalian Akt1/PKBa isof o r ms
have been identified.
WB: 1:5,000-10,000
IHC: 1:100
ICC: 1:100-1:250
Flow Cytometry: 1:20
IP: 1:100
A. Western blot analysis on MCF-7 cell lysate using
anti- Akt1/PKBa (C-term) RabMAb (cat. #1081-1);
dilution 1:10,000.
B. Immunohistochemical analysis of
paraffin-embedded prostate carcinoma using
anti-Akt1/PKBa (C-term) RabMAb (cat. #1081-1).