质量标准:【产品介绍】CrkL (Crk-like), a 36kDa protein
predominantly expressed in hematopoietic cell lines, is
a member of the Crk adapter protein family. Lacking
any intrinsic enzymatic activity, CrkL is composed of
one SH2 domain a n d two SH3 domains (1). The SH2 domain
of CrkL as been shown to interact with c-Cbl, Cas, Hef-1
a n d Paxillin (2); while the N-terminal SH3 can bind
to c-ABL, Sos1 a n d C3G (3). Additionally, the phosph
o r ylated f o r m of CrkL (pY207) binds to BCr-ABL
oncogene in chronic myelogenous leukemia cells (4).
WB: 1:50,000
IP: 1:50
A. Western blot analysis on K562 cell lysates
using anti-Phospho-CrkL (pT207) RabMAb
(cat. #1888-1), 1:50,000 dilution. Cells were
either (A) untreated (B) treated with AP