质量标准:【产品介绍】Cystatin B is a member of the cysteine
protease inhibitor superfamily, functioning as
an intracellular protease inhibitor (1). It plays a role
in inhibiting cysteine proteinases and
protecting proteinases from lysosomal leakage (1, 2).
The second hairpin loop and the C-terminal end of
Cystatin B anchor the inhibitor to target proteinases (3).
A deficiency in cystatin B is observed in
progressive myoclonic epilepsy type 1 (1). This
deficiency predisposes neurons to oxidative stress
that leads to neuronal death and degeneration (1).
In addition, Cystatin B has been linked to amyloid
fibril formation in vitro and is overexpressed
in hepatocellular carcinoma (4, 5).
Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1: 1,000 - 10,000
ICC: 1: 250 - 500
Species Reactivity
Human
Products Data
Western blot analysis on (A) human bladder and (B)
U87-MG cell lysates using anti-Cystatin B RabMAb
(cat. # 2842-1).
Specificity
A synthetic peptide corresponding to residues in
human Cystatin B was used as an immunogen.
贮存:Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.