质量标准：【产品介绍】Keratins, the intermediate filament proteins
of epithelial cells, connect to desmosomes, the
cell-cell adhesion structures at the surface membrane.
Among the various intermediate filament (IF)
proteins, cytokeratin 8 (CK8) is especially remarkable as
it is produced early in embryogenesis, is the only
type-II CK occurring in many simple epithelial cells,
a n d can also be synthesized in certain
non-epithelial cells (1). Keratin 8 a n d 18 (CK8/18)
are the maj o r keratin pair in simple-type epithelia,
as found in the liver, pancreas, a n d intestine (2).
While K8/K18 are essential f o r maintaining
structural integrity, there is accumulating
evidence indicating that they also exert
non-mechanical functions. It has been rep o r ted
that K8/K18-free hepatocytes from K8-null mice are
m o r e sensitive to Fas-mediated apoptosis, in line with
an increased Fas density at the cell surface a n d
an altered c-Flip regulation of the anti-apoptotic
ERK1/2 signaling pathway (3).
WB: 1:25,000 50,000
IHC: 1:250 500
ICC: 1:100 250
Flow Cytometry: 1:20
IP: 1:70
A. Western blot analysis on A431 cell lysate using
anti-CK8 RabMAb(cat. # 2032-1), dilution 1:50,000.
B. Immunohistochemical analysis of paraffin-embedded
human breast adenocarcinoma using anti-CK8
RabMAb (cat. #2032-1).
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