质量标准:【产品介绍】E-Cadherin, a member of the
cadherin superfamily, is implicated as a key player
in different cellular processes including development,
m o r phology, polarity, migration a n d tissue
integrity (1-2). E-cadherin is a glycoprotein with
an extracellular domain that interacts with other
E-cadherin molecules on adjacent cells, thereby
establishing adhesion between epithelial cells.
Established as a tum o r a n d metastasis suppress
o r , E-cadherin expression is frequently down-regulated
o r extinguished in malignancy which strongly c o r
relates with po o r prognosis (3-4). Mutations in
E-cadherin are found in gastric, breast, col o r
ectal, thyroid a n d ovarian cancer (5).
WB: 1:100,000 – 1,000,000
IHC: 1:100 – 250
ICC: 1:250 – 500
IP: 1:40
A. Western blot analysis on human brain lysates
using anti-Phospho-E-Cadherin (pS838/840) RabMAb
(cat. #2239-1), 1:1,000,000 dilution. Cells were
either (A) untreated (B) treated with AP
B. Immunohistochemical analysis of paraffin-embedded
human breast carcinoma using Phospho-anti-E-Cadherin
RabMAb. (cat. #2239-1)
C. Immunohistochemical analysis of paraffin-embedded
human cervical carcinoma using Phospho-E-Cadherin
RabMAb.(cat.#2239-1).