质量标准：【产品介绍】Transcriptional Regulator ERG belongs to the
ETS family that is involved in the regulation of a
wide variety of cellular and developmental processes
(1). This family of transcription factors
contains approximately 30 members that share a
highly conserved DNA-binding domain (ETS domain) (2, 3)
and differs from each other in other domains (such
as absence or presence of the Pointed/SAM domain) and
are thus distinguished in sub-families (1). ERG belongs
to the Erg/Fli-1 sub-family. It has been widely studied
for its involvement in human cancers; TMPRSS2-ERG
fusion, which occurs on account of translocations
and interstitial deletions, is implicated in
aggressive forms of prostate cancer (4, 5). ERG is linked
to normal processes such as mesoderm formation and is
found to form functional complexes with Jun/Fos, with
the resulting ternary complexes regulating expression
of genes such as metalloprotease-1 (MMP-1) and MMP-3 (1).
It may also participate in transcriptional
regulation through the recruitment of SETDB1
histone methyltransferase and subsequent modification
of local chromatin structure (2).
Recommended Applications
ICC
Applications and Recommended Dilution Factors
ICC: 1:50 - 100
Species Reactivity
Human
Products Data
Immunofluorescent analysis of LnCaP cells using
anti-ERG RabMAb (DyLight® 488 conjugate,
cat.# 4583-1) (green) and dapi (blue).
Specificity
A synthetic peptide corresponding to residues on
the C-terminus in human ERG was used as an immunogen.
This antibody also detects Fli-1.
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