质量标准:【产品介绍】Fgr (c-fgr) is a member of the Src family
of non-receptor protein-tyrosine kinases (PTK’s), which
are involved in the intracellular signal transduction
for growth and differentiation of the cells. Fgr consists
of divergent N-terminal region which is involved
in myristylation and palmitylation, conserved SH2 and
SH3 internal domain involved in mediating protein-to-
protein interactions with phosphotyrosine-containing
and proline-rich motifs, and highly conserved
C-terminal region tyrosine kinase catalytic domain. Fgr
is commonly expressed in cells with hematopoietic
origin (e.g. Myeloid cells, NK cells, B cells). Localized
in the plasma membrane ruffles, Fgr functions as a
negative regulator of cell migration and adhesion
triggered by the beta-2 integrin signal
transduction pathway. Overexpression of Fgr is seen as
a result of Epstein-Barr Virus (EBV) infection (4).
Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:10 - 100
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis
Products Data
Western blot analysis on Raji cell lysate using
anti-Fgr RabMAb (cat. # 2517-1).
Specificity
A synthetic peptide corresponding to C-terminus of human
FGR was used as an immunogen.