质量标准:【产品介绍】Gab2 (Grb2-associated binder-2) is an adapt
o r protein involved in numerous intracellular
signaling pathways via its interaction with recept
o r tyrosine kinases (RTKs), growth fact o r s
a n d cytokines. Gab2 is a substrate of various
RTKs, including EGFR, insulin recept o r , cytokine recept
o r s as well as B a n d T cell antigen recept o r s;
Gab2 acts as a docking protein f o r several
SH2-containing proteins (1-3). Upon tyrosine phosph
o r ylation, Gab2 interacts with SHP2 tyrosine phosphatase
a n d GRB2 adapt o r protein PI3-kinase, CrkL a n d
SHC (4-5).
WB: 1:500
ICC: 1:50
Flow Cytometry: 1:20
IP: 1:50
A. Western blot analysis of anti-Gab2 RabMAb
(cat. # 1631-1), dilution 1:500. A: K562 B: MCF-7
B. Immunoflu o r escent staining of PC-12 cells
using anti-Gab-2 RabMAb (cat. # 1631-1).