质量标准:【产品介绍】Guanine nucleotide binding protein beta-2
(GNB2) is a G-protein subunit belonging to WD repeat
G protein beta family. GNB2 functions as a modulator
or transducer for trans-membrane signaling pathway
systems. G-protein is composed of alpha, beta, and
gamma subunits, where beta and gamma subunits are
required for GTPase activity and G-protein
effector interaction (1). Specifically, GNB2 interacts
with the glucocorticoid and migrates into the nucleus
to suppress GR-induced trans-activation of
the glucocorticoid-responsive genes (2). GNB2 has
been identified as a binding partner to Ataxin 10,
an important target in SCA10 disorder, and also a partner
in regulating NTE, a protein known to cause
delayed neuropathy with degeneration of nerve axon (3, 4).
Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:100 - 250
Species Reactivity *
Human, Mouse, Rat
*Cross reactivity determined by western blot only.
Products Data
A. Western blot analysis on A) SH-SY5Y, B) Jurkat,
and C) NIH3T3 lysates using anti-GNB2 RabMAb (cat. #2515-1).
Specificity
A peptide corresponding to residues near N-term of
human GNB2 was used as an immunogen.
贮存:Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.