质量标准:【产品介绍】HLA-C belongs to the HLA class I heavy
chain paralogues. This class I molecule is a
heterodimer consisting of a heavy chain and a light
chain (beta-2 microglobulin). The heavy chain is anchored
in the membrane. Class I molecules play a central role
in the immune system by presenting peptides derived
from endoplasmic reticulum lumen. They are expressed
in nearly all cells. The heavy chain is approximately
45 kDa. Mutations in HLA-C are responsible for the
peptide binding specificity of each class one
molecule. Typing for these polymorphisms is routinely
done for bone marrow and kidney transplantation (1).
Recommended Applications
WB, IP
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IP: 1:10 - 100
Species Reactivity *
Human, Mouse, Rat
*Species cross-reactivity is based on WB analysis.
Products Data
Western blot analysis on (A) Jurkat, (B) human melanoma,
(C) human placenta, (D) 293T, and (E) A375 lysates
using anti-HLA-C RabMAb (cat. #5472-1).
Specificity
A synthetic peptide corresponding to residues in human
HLA-C was used as an immunogen.