质量标准:【产品介绍】Integrin beta-1 (ITGB1, CD29, VLA-beta) is
the beta subunit found in the integrin families, forming
a heterodimer integrin receptor through non-covalent
bonding with various integrin alpha subunits.
Integrin heterodimer containing Integrin beta-1 binds
to various cell surface and extracellular proteins
(CD49a-f, CD51) to mediate cell to cell and cell to
matrix adhesion (1). Integrin beta-1 plays a critical
role in the cell adhesion and recognition in
embryogenesis, hemostasis, immune response, tissue
repair, metastatic diffusion of tumor cells and
development (2, 3, 4). Observations argue that tyrosines
783 and 795 within the cytoplasmic tail of integrin
subunit beta1A are critical mediators of FAK activation
and cell spreading in GD25 cells (5).
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:10,000-50,000
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data
A. Western blot analysis on U937 cell lysates
using anti-Phospho-Integrin beta-1 (CD29) (pY783)
RabMAb (cat. #2172-1). Cells were either (A) untreated
(B) treated with pervanadate.
Specificity
A phospho specific peptide corresponding to
residues surrounding Tyrosine 783 of human Integrin
β-1 (CD29). This antibody detect Integrin
β-1 phosphorylated at Tyrosine 783.