质量标准:【产品介绍】Jak2 is a member of the Janus family
tyrosine kinases (Jaks), whose function is to
transduce extracellular signals from cytokines
a n d interferons. Jaks associate with cytokine recept
o r s; upon lig a n d binding, Jaks phosph o r ylate
the recept o r . The phosph o r ylated recept o r s
are bound by SH2-containing proteins, one class of which
is the signal transducers a n d activat o r s
of transcription (STATs). Activated STATs, then,
translocate to the nucleus to mediate gene
transcription (1,2). Tyr1007/1008 of Jak2 are the
homologous Tyr1054/1055 in Tyk2, a n d phosph o r ylation
at these residues is needed f o r Tyk2 activation (3).
A chromosomal aberration involving Jak2 is found in a
f o r m of pre-B acute myeloid leukemia (4).
WB: 1:5,000-10,000
IHC: 1:50-100
ICC: 1:50100
IP: 1:50
A. Western blot analysis of immunoprecipitation pellets
from Jurkat cell lysate +GM-CSF (catalog #1477-1),
dilution 1:50.
B. Immunohistochemical analysis of paraffin-embedded
human lung adenocarcinoma using anti-JAK-2
(pY1007/1008) RabMAb (catalog #1477-1).
C. Dot Blot analysis on immunogen phospho-peptide (A)
a n d non-phospho peptide (B) using anti-Jak2
(pY1007/1008) RabMAb (cat. # 1477-1) dilution 1:1,000