Quality Standard：【产品介绍】The 14-3-3 epsilon protein (14-3-3E) is one
of seven isoforms in the 14-3-3 protein family,
which consists of acidic proteins expressed at
high levels in neurons of the central nervous
system (1). It is an adaptor protein implicated in
the regulation of a large spectrum of both general
and specialized signaling pathways. 14-3-3E binds
to a large number of partners, usually by recognition
of a phosphoserine or phosphothreonine motif (2).
It also interacts with both insulin-like growth
factor I receptor (IGFIR) and insulin receptor
substrate I (IRS-1), suggesting its role in the
regulation of insulin sensitivity (3). 14-3-3E has
also been implicated in the pathogenesis of small cell
lung cancer (4).
Recommended Applications
WB, ICC, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:100 - 250
FC: 1:10 - 100
Species Reactivity
Human, Mouse, Rat
Specificity
A synthetic peptide corresponding to residues in human 14-3-3E was used as an immunogen.
Storage：Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05%
BSA. Stable for 12 months from date of receipt.
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