Quality Standard:【产品介绍】Akt1/PKBa is a Ser/Thr protein kinase
whose kinase activity plays a key role in various
cellular functions, including apoptosis, glycogen
synthesis, a n d cell growth . Akt1/PKBa is activated
by various growth a n d survival fact o r s (1).
Phosph o r ylation on Thr308, Ser473 a n d Tyr474
is required f o r full activity. Akt1/PKBa
inhibits apoptosis by phosph o r ylating a n d
inactivating several targets, including
caspase-9 (2). Akt1/PKBa regulates glycogen synthesis
by phosph o r ylating a n d inactivating glycogen
synthase kinase-3a a n d b (3,4). Three mammalian
Akt1/PKBa isof o r ms have been identified.
IHC: 1:1,000-1:2,500
ICC: 1:1,000
IP: 1:100
A. Immunohistochemical analysis of
paraffin-embedded squamous lung carcinoma
using anti-Akt1/PKBa RabMAb (cat. #1085-1).