Quality Standard:【产品介绍】Akt1/PKBa is a Ser/Thr protein kinase
whose kinase activity plays a key role in various
cellular functions, including apoptosis, glycogen
synthesis, a n d cell growth . Akt1/PKBa is activated
by various growth a n d survival fact o r s (1).
Phosph o r ylation on Thr308, Ser473 a n d Tyr474
is required f o r full activity. Akt1/PKBa
inhibits apoptosis by phosph o r ylating a n d
inactivating several targets, including
caspase-9 (2). Akt1/PKBa regulates glycogen synthesis
by phosph o r ylating a n d inactivating glycogen
synthase kinase-3a a n d b (3,4). Three mammalian
Akt1/PKBa isof o r ms have been identified.
WB: 1:10,000
A. Western blot analysis on NIH3T3 cell lysate using
anti- Akt1/PKBα RabMAb (cat. #1086-1); dilution 1:10,000.