Quality Standard：【产品介绍】Bax is a pro-apoptotic member of the
Bcl-2 family of proteins. During
mitochondria-regulated programmed cell death, Bax
promotes apoptosis by binding Bcl-2 a n d inhibiting
its anti-apoptotic function (1). Upon apoptotic
stimulation, Bax translocates from the cytosol to
the mitochondrial membrane (2). Through interactions
with mitochondrial membrane proteins, Bax increases
the membrane''s permeability, leading to the release
of cytochrome c from mitochondria a n d initiation of
the apoptotic caspase cascade (2,3).
WB: 1:1,000 - 2,000
IHC: 1:250
ICC: 1:100
A. Western blot analysis on HeLa cell lysate using
anti-Bax RabMAb (cat. #1063-1), 1:2,000 dilution.
B. Immunohistochemical analysis of paraffin-embedded
human lymph node using anti-Bax RabMAb (cat. #1063-1).
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