Quality Standard:【产品介绍】Bcl-10 is an adapt o r protein with a
caspase recruitment domain (CARD) that promotes apoptosis
a n d activates pro-caspase 9 a n d NF-kB (1-2).
Bcl-10 also interacts with other CARD domain
containing proteins including CARD9, 10, 11 a n d 14.
Bcl-10 is found to f o r m a complex with MALT1, a
protein known to be translocated in MALT lymphomas. Bcl-10
a n d MALT1 play a critical role in antigen recept
o r mediated lymphocyte proliferation a n d signaling
to NF-B, which controls the expression of genes critical
f o r cell survival, proliferation, a n d immune
responses (3-4). Defects in Bcl-10 have been identified
in various types of cancer.
WB: 1:1,000-5,000
IHC: 1:100-250
ICC: 1:100-250
IP: 1:50
A. Western blot analysis on Raji cell lysate
using anti-Bcl-10 (C-term) RabMAb (cat. # 1651-1),
dilution 1:5,000.
B. Immunohistochemical analysis of paraffin-embedded
human hepatocellular carcinoma using anti-BCL-10
(C-term) RabMAb (cat. # 1651-1).
C. Immunoflu o r escent staining of HeLa cells
using anti-BCL-10 (C-term) RabMAb (cat. # 1651-1).