Quality Standard:【产品介绍】Bcl-10 is an adapt o r protein with a
caspase recruitment domain (CARD) that promotes apoptosis
a n d activates pro-caspase 9 a n d NF-kB (1-2). Bcl-10
also interacts with other CARD domain containing
proteins including CARD9, 10, 11 a n d 14. Bcl-10 is
found to f o r m a complex with MALT1, a protein known to
be translocated in MALT lymphomas. Bcl-10 a n d MALT1 play
a critical role in antigen recept o r mediated
lymphocyte proliferation a n d signaling to NF-B,
which controls the expression of genes critical f o r
cell survival, proliferation, a n d immune responses
(3-4). Defects in Bcl-10 have been identified in
various types of cancer.
WB: 1:2,000
IHC: 1:50
Flow Cytometry: 1:20
IP: 1:30
A. Western blot analysis on Raji cell lysate
using anti-Bcl-10 RabMAb (cat. # 1680-1), dilution 1:2,000.
B. Immunohistochemical analysis of paraffin-embedded
human colon carcinoma using anti-Bcl-10 RabMAb
(cat. # 1680-1).