Quality Standard:【产品介绍】Bim, Bcl-2 interacting mediat o r of cell
death, is a pro-apoptotic protein belonging to the
BH3-only group of Bcl-2 family members (1). Bim
promotes apoptosis by binding to a n d inhibiting
the activity of anti-apoptotic Bcl-2 family
members, inducing the release of cytochrome c
from mitochondria (2). Bim is sequestered in an
inactive conf o r mation through binding to the
microtubule-associated dynein mot o r complex.
Certain apoptotic stimuli release Bim from
microtubules, allowing inhibit o r y binding
to anti-apoptotic Bcl-2 family members a n d
subsequent iniation of apoptosis (3,4).
WB: 1:500
IHC: 1:100
ICC: 1:100
IP: 1:40
A. Western blot analysis on A431 cell lysate using
anti-Bim RabMAb (cat. #1036-1), dilution 1:500.
B. Immunohistochemical analysis of paraffin-embedded
breast carcinoma using anti-Bim RabMAb (cat. #1036-1).