Quality Standard:【产品介绍】Btk (Bruton tyrosine kinase also known as BPK
o r ATK) is a member of the TEC family of non-recept
o r protein tyrosine kinase which includes Bmx, Itk
a n d TEC. Btk is composed of a pleckstrin domain, an SH3
a n d SH2 domain, a catalytic kinase domain a n d a
TEC homology domain (1). BTK plays a crucial role in B
cell activation a n d development (2). Similar to
Etk-TNFR2 interaction, Btk interacts with Fas, a member
of the TNFR family involved in apoptosis in a lig
a n d -independent manner (3) Mutations in the Btk gene
have been linked to severe developmental blocks in
human B-cell ontogeny leading to X-linked
agammaglobulinemia (XLA). Patients with this disease
are unusually prone to bacterial infection but not to
viral infection.
WB: 1:500
IP: 1:20
A. Western blot analysis on Daudi cell lysate using
anti-Btk (C-term) RabMAb (cat. #1599-1), 1:500 dilution