Quality Standard:【产品介绍】Caspase-2 (Nedd2/ICH-1) is part of a family
of aspartate-specific cysteine proteases that participate
in programmed cell death, o r apoptosis. Caspase-2
is localized to the nucleus, a n d has been shown to
play roles in both positive a n d negative regulation
of apoptosis (1). Upon apoptotic stimulation,
pro-caspase-9 is cleaved in a series of steps to produce
an 18-kDa large subunit a n d a 12-kDa small fragment
(2). Caspase-2 can be a nuclear initiat o r caspase, as
it has been shown to precede the processing a n d
activation of caspase-8, -9, a n d -3 (3). Caspase-2
might also act as an effect o r caspase; in
apoptotic pathways resulting from UV-induced DNA
damage, processing of caspase-2 occurs downstream
of caspase-9 a n d caspase-3 activation (4).
WB: 1:500
IP: 1:20
A. Western blot analysis on Jurkat cell lysate
using anti-Caspase-2 RabMAb (catalog #1552-1),
dilution 1:500.