Quality Standard：【产品介绍】CD209 is a transmembrane receptor and is
often referred to as DC-SIGN because of its expression
on the surface of dendritic cells and macrophages. It
is involved in the innate immune system and
recognizes numerous evolutionarily divergent
pathogens, ranging from parasites to viruses with a
large impact on public health. CD209 is organized into
three distinct domains: an N-terminal transmembrane
domain, a tandem-repeat neck domain and C-type
lectin carbohydrate recognition domain. The
extracellular region consisting of the C-type lectin
and neck domains has a dual function as a
pathogen recognition receptor and a cell adhesion
receptor by binding carbohydrate ligands on the surface
of microbes and endogenous cells. The neck region
is important for homo-oligomerization which allows
the receptor to bind multivalent ligands with high
avidity. Variations in the number of 23 amino acid
repeats in the neck domain of this protein are rare but
have a significant impact on ligand binding ability.
CD209 is closely related in terms of both sequence
and function to a neighboring protein L-SIGN. DC-SIGN
and L-SIGN differ in their ligand-binding properties
and distribution (1).
Recommended Applications
WB, IHC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:50 - 100
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis.
Products Data
Western blot analysis on (A) HACAT, (B) fetal skin,
(C) fetal artery, and (D) human small intestine
lysates using anti-CD209 RabMAb (cat. #5232-1).
Immunohistochemical analysis of paraffin-embedded
human placenta tissue using anti-CD209 RabMAb (cat.# 5232-1).
Specificity
A synthetic peptide corresponding to residues in human
CD209 was used as an immunogen.
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