Quality Standard：【产品介绍】CD44 is a cell-surface glycoprotein
postulated to play a role in a variety of
biological processes, including lymphocyte homing a n d
tum o r -cell metastasis. Several isof o r ms of CD44
have been identified in human cells, a n d the genesis
of some of these isof o r ms has been attributed
to alternative splicing. Underst a n d ing of
mechanisms regulating CD44 alternative splicing may
provide insights into diverse processes, including tum
o r -cell metastasis a n d lymphocyte homing (1).
The deduced protein sequence of 699 amino acids has a
novel 339 amino acid domain i n s e r t ed into the
proximal extracellular domain of the st a n d ard,
leukocyte f o r m of CD44. The additional domain adds
a number of potential N- a n d O-linked glycosylation
sites a n d two proteolysis sites to this f o r m of
CD44 (2). CD44 is defined as a structurally diverse,
but immunologically related, set of intrinsic
membrane macromolecules, a n d suggests that
these structurally varied f o r ms might be expected
to manifest multiple functions (3)
WB: 1:5000
IHC: 1:100 250
ICC: 1:100 250
Flow Cytometry: 1:30
A. Western blot analysis on TF-1 cell lysate
using anti-CD-44 RabMAb (cat. # 1998-1), dilution 1:5000.
B. Immunohistochemical staining of paraffin-embedded
human urinary bladder using anti-CD-44 RabMAb (cat. #1998-1).
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