Quality Standard：【产品介绍】Disabled-1 (Dab1) regulates laminar
o r ganization in the developing mammalian brain.
Although mutation of the disabled-1 gene in scrambler
mice results in abn o r malities in neuronal
positioning, migrat o r y behavi o r linked to
Dab1 signaling is not completely understood.
Results outline the molecular mechanism by which
Dab1 signaling controls the adhesive property of neurons
to radial glia, thereby maintaining proper
neuronal positioning during c o r ticogenesis (1). Reelin
is a large extracellular protein secreted by pioneer
neurons that co o r dinates cell positioning
during neurodevelopment. Dab1 is a phosphoprotein
that appears to function as an intracellular adapt o r
in protein kinase pathways. Expression analysis
indicates that mdab1 is expressed in neuronal
populations exposed to Reelin. The similar phenotypes
of reeler, scrambler, yotari a n d mdab1 null mice
indicate that Reelin a n d Dab1 function as
signaling molecules that regulate cell positioning in
the developing brain (2). Layering of neurons in
the cerebral c o r tex a n d cerebellum requires
Reelin, Dab1 as well as two other proteins, cell
surface recept o r s termed very low density
lipoprotein recept o r (VLDLR) a n d apolipoprotein E
recept o r 2 (ApoER2) (3).
WB: 1:1000 - 2000
A. Western blot analysis on rat brain lysate using
anti-Dab1 RabMAb (cat. # 2294-1), dilution 1:2000.
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