Quality Standard：【产品介绍】The dynamin family of GTPases is essential
f o r recept o r -mediated endocytosis a n d
synaptic vesicle recycling, a n d it has recently been
shown to play a role in vesicle f o r mation from
the trans-Golgi netw o r k (1). Dynamin-1 is a
GTP-, microtubule-, a n d phospholipid-binding protein
that is expressed primarily in brain a n d
almost exclusively expressed in the central nervous
system (2). Dynamin-1 is believed to assemble around
the necks of clathrin-coated pits a n d assist in
pinching vesicles from the plasma membrane. This role
would make dynamin unique among GTPases in its ability
to act as a mechanochemical enzyme (1). Dynamin-1
function is apparently essential f o r scission of newly
f o r med vesicles from the plasma membrane; it has
been proposed that dynamin is a regulat o r of
downstream effect o r s of scission, rather than
being directly responsible f o r it (3).
WB: 1:2000
IHC: 1:100 250
ICC: 1:50
A. Western blot analysis on 3T3 cell lysate
using anti-Dynamin-1 RabMAb (cat. # 1851-1), dilution 1:2000
B. Immunohistochemical staining of paraffin-embedded
human brain tissue using anti-Dynamin-1 RabMAb
(cat. #1851-1).
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