Quality Standard:【产品介绍】Epidermal growth fact o r recept o r (EGFR) is
a 170 kDa transmembrane glycoprotein recept o r
tyrosine kinase that, activated by epidermal growth fact
o r (EGF), affects cell growth a n d differentiation
(1). Binding of EGF o r TGF alpha to EGFR activates
tyrosine kinase activity of the recept o r (2). Phosph
o r ylation of Tyr 992, Tyr 1068 a n d Tyr 1086 is
required f o r conf o r mational change in the C-terminal
of EGFR (3). Autophosph o r ylation of Tyr 992
c r e a t e s a binding site f o r the phospholipase
C-gamma (PLC-gamma) SH2 domain, inducing
downstream signaling (4).
WB: 1:5,000
IHC: 1:10-25
ICC: 1:10
IP: 1:10
A. Western blot analysis of A431 cell lysate using anti
EGFR RabMab, (cat# 1114 -1) dilution 1:5,000
B. Immunohistochemical anlysis of human cervical
carcinoma using anti EGFR RabMab, cat# 1114 -1
C. Immunoflu o r escent staining of A431 cells using
anti EGFR RabMab, cat# 1114 -1