Quality Standard:【产品介绍】Emtk/Itk/Tsk is a member of the Tec family
of Protein Tyrosine Kinase (PTK) expressed in T, NK,
a n d mast cells (1). Structurally, Emtk/Itk/Tsk possesses
a tyrosine kinase (TK), a pleckstrin homology (PH) a n d
a TEC homology domain. It also contains both SRC
homology 2 (SH2) a n d a SRC homology 3 (SH3) domains
(2). It lacks as well the amino-terminal
myristylation signal a n d the negative aut o r egulat
o r y phosph o r ylation site present in all members of
the Src family of PTKs (3). Additionally, the Src
tyrosine kinase LCK is required f o r
Emtk/Itk/Tsk activation a n d recruitment by CD28 (4).
WB: 1:1,000
Flow Cytometry: 1:50
IP: 1:50
A. Western blot analysis on Jurkat cell lysate
using anti-Emtk/Itk/Tsk (C-term) Rabbit Monoclonal
(cat. # 1595-1), dilution 1:1,000.