Quality Standard:【产品介绍】Emtk/Itk/Tsk is a member of the Tec family
of Protein Tyrosine Kinase (PTK) expressed in T, NK,
a n d mast cells (1). Structurally, Emtk/Itk/Tsk possesses
a tyrosine kinase (TK), a pleckstrin homology (PH) a n d
a TEC homology domain. It also contains both SRC homology
2 (SH2) a n d a SRC homology 3 (SH3) domains (2). It
lacks as well the amino-terminal myristylation signal
a n d the negative aut o r egulat o r y phosph o r
ylation site present in all members of the Src family
of PTKs (3). Additionally, the Src tyrosine kinase LCK
is required f o r Emtk/Itk/Tsk activation a n d
recruitment by CD28 (4).
WB: 1:1,000-5,000
IHC: 1:250-500
Flow Cytometry: 1:80
IP: 1:50
A. Western blot analysis on Jurkat cell lysate
using anti-Emtk/Itk/Tsk (N-term) Rabbit Monoclonal
(cat. # 1625-1), dilution 1:5,000.
B. Immunohistochemical analysis of paraffin-embedded
human lymph node using anti- Emtk/Itk/Tsk (N-term)
RabMAb (cat. # 1625-1).