Quality Standard：【产品介绍】EPS15 a n d EPS15R are substrates of
the epidermal growth fact o r (EGF) recept o r kinase
that are characterized by the presence of a protein:
protein interaction domain, the EH domain, a n d by
their ability to bind to the clathrin adapt o r
protein complex adapt o r protein 2. Evidence suggests
that eps15 a n d eps15R are involved in endocytosis (1).
The most striking difference between these two
related proteins is that Eps15R is also found in
the nucleus, whereas Eps15 is excluded from this
compartment at steady state (2). Eps15R plays a key role
in clathrin-mediated endocytosis of transmembrane recept
o r s. Using a mutational approach, it has been found
that the second ubiquitin-interacting motif (UIM) of Eps15
a n d Eps15R is essential f o r their ubiquitination (3).
WB: 1:50,000
IHC: 1:100 250
ICC: 1:50 100
Flow Cytometry: 1:10
IP: 1:70
A. Western blot analysis on Hela cell lysate
using anti-EPS15R RabMAb (cat. # 1857-1), dilution 1:50,000.
B. Immunohistochemical staining of paraffin-embedded
human breast carcinoma using anti-EPS15R RabMAb
(cat. #1857-1).
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