Quality Standard：【产品介绍】FABP7 is a member of the large family
of hydrophobic ligand-binding proteins (FABPs) (1).
FABP proteins are involved in lipid metabolism,
including uptake and intracellular trafficking of
fatty acids and retinoids. In addition, they play a role
in gene regulation, cell signaling, cell growth
and differentiation. Several reports have suggested
a possible role for the different FABP proteins in
cancer biology, linking their levels with either
increasing or decreasing the degree of malignancy.
Nine FABPs (FABP1-FABP9) have been identified (2). FABP7
is a brain-specific protein that is required for
the establishment of the radial glial fiber system in
the developing brain, a system that is necessary for
the migration of immature neurons to establish
cortical layers (3). It is expressed at high levels in
the developing central nervous system (4). FABP7 has
also been found in melanocytic lesions and has shown
to regulate proliferation and invasion in melanoma cells
in vitro, suggesting that it may play a role in
cell proliferation and invasion (2).
Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:10 - 100
Species Reactivity
Human
Products Data
Western blot analysis on Fetal brain cell lysate
using anti-FABP7 RabMAb (cat. #2831-1).
Specificity
A synthetic peptide corresponding to residues in human
FABP7 was used as an immunogen.
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