Quality Standard：【产品介绍】Focal adhesion kinase (FAK) is a non-recept
o r protein-tyrosine kinase implicated in signaling
pathways involved in cell motility, proliferation
a n d apoptosis (1). FAK is composed of a central
catalytic domain flanked by large N- a n d
C-terminal regions. FAK is activated by phosph o r
ylation at tyrosine 397 in response to integrin
clustering which can be induced by cell adhesion
o r antibody cross-linking o r via G-protein-coupled
recept o r (GPCR) occupancy by lig a n d s such as
bombesin o r lysophosphatidic acid (2-3). FAK expression
is upregulated in various tum o r s (4). Increased
FAK expression has been c o r related with the
enhanced motility a n d invasiveness of human tum o r
cells, as well as with promoting increased
cell proliferation (5).
WB: 1:1,000
IHC: 1:50-100
ICC: 1:250-500
IP: 1:50
A. Western blot analysis on Hela cell lysate using
anti-FAK RabMAb (cat. # 1700-1), dilution 1:1,000.
B. Immunohistochemical analysis of paraffin-embedded
human hepatocellular carcinoma using anti-FAK RabMAb
(cat. # 1700-1).
C. Immunoflu o r escent staining of HeLa cells
using anti-FAK RabMAb (cat. # 1700-1).
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