Quality Standard：【产品介绍】Fibroblast growth factors (FGFs) are
polypeptide mitogens that induce the proliferation of a
wide variety of cell types (1). Fibroblast growth
factor (FGF)/FGF receptor (FGFR1) signaling plays a
crucial role in mesoderm formation and patterning.
Studies suggest that FGFR1, among the different FGFRs,
may play a role in cardiogenesis. Data point to
a nonredundant role for FGFR1-mediated signaling
in cardiomyocyte development (2). It has also been
shown that during development, FGFR1 is required for
the generation of the precursor pool, which gives rise
to the auditory sensory epithelium. Data also suggest
that FGFR1 might have a distinct later role in
intercellular signaling within the differentiating
auditory sensory epithelium (3). Highly conserved FGF-D2
and FGF-linker (between D2-D3) interfaces define a
general binding site for all FGF-FGFR complexes.
Specificity is achieved through interactions between
the N-terminal and central regions of FGFs and two
loop regions in D3 that are subject to alternative
splicing. These structures provide a molecular basis
for FGF1 as a universal FGFR ligand and for modulation
of FGF-FGFR specificity through primary sequence
variations and alternative splicing (4).
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:500
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data
A. Western blot analysis on SH-SY-5Y cell lysate
using anti-FGFR1 RabMAb (cat. # 2144-1), dilution 1:500.
Specificity
A synthetic peptide corresponding to residues near
the C-terminus of human FGFR1 was used as an immunogen.
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