Quality Standard：【产品介绍】FKBP4 is a member of the immunophilin
protein family, which play a role in immunoregulation
and basic cellular processes involving protein folding
and trafficking. This protein is a cis-trans
prolyl isomerase that binds to the immunosuppressants
FK506 and rapamycin. It has high structural and
functional similarity to FK506-binding protein 1A
(FKBP1A), but unlike FKBP1A, this protein does not
have immunosuppressant activity when complexed with
FK506. FKBP4 interacts with interferon regulatory
factor-4 and plays an important role in
immunoregulatory gene expression in B and T lymphocytes.
It is known to associate with phytanoyl-CoA
alpha-hydroxylase, and it can also associate with two
heat shock proteins (hsp90 and hsp70) and thus may play
a role in the intracellular trafficking of
hetero-oligomeric forms of the steroid hormone
receptors. FKBP4 correlates strongly with
adeno-associated virus type 2 vectors (AAV) resulting in
a significant increase in AAV-mediated transgene
expression in human cell lines. Thus this protein is
thought to have important implications for the optimal
use of AAV vectors in human gene therapy (1).
Recommended Applications
WB, IHC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:50,000 - 200,000
IHC: 1:100 - 250
IP: 1:10 - 100
FC: 1:10 - 100
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis.
Products Data
Western blot analysis on (A) HeLa, (B) MCF-7,
(C) Jurkat, and (D) K562 cell lysates using
anti-FKBP4 RabMAb (cat. #5241-1).
Immunohistochemical analysis of paraffin-embedded
human breast tissue using anti-FKBP4 RabMAb (cat. #5241-1).
Specificity
A synthetic peptide corresponding to residues near
the C-terminus of human FKBP4 was used as an immunogen.
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