Quality Standard：【产品介绍】Flavin-containing monooxygenases (FMO) are
an important class of drug-metabolizing enzymes
that catalyze the NADPH-dependent oxygenation of
various nitrogen-,sulfur-, and phosphorous-
containing xenobiotics such as therapeutic drugs,
dietary compounds, pesticides, and other foreign
compounds. The human FMO family is composed of 5
proteins. FMO members have distinct developmental-
and tissue-specific expression patterns. The expression
of FMO3, the major FMO expressed in adult liver, can vary
up to 20-fold between individuals. This
inter-individual variation in FMO3 expression levels
is likely to have significant effects on the rate at
which xenobiotics are metabolised and, therefore, is
of considerable interest to the pharmaceutical
industry. This transmembrane protein localizes to
the endoplasmic reticulum of many tissues. Mutations in
FMO3 cause the disorder trimethylaminuria (TMAu), which
is characterized by the accumulation and excretion
of unmetabolized trimethylamine and a distinctive body
odor. In healthy individuals, trimethylamine is
primarily converted to the non-odorous
trimethylamine N-oxide (1).
Recommended Applications
WB, IHC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:500 - 1000
Species Reactivity *
Human, Mouse, Rat
*Species cross-reactivity is based on WB analysis.
Products Data
Western blot analysis on (A) fetal liver and (B)
fetal kidney lysates using anti-FMO3 RabMAb (cat. #5526-1).
Immunohistochemical analysis of paraffin-embedded
human liver tissue using anti-FMO3 RabMAb (cat.# 5526-1).
Specificity
A synthetic peptide corresponding to residues in human
FMO3 was used as an immunogen.
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