Quality Standard:【产品介绍】Gab1 (Grb2-associated binder-1) is an adapt
o r protein that serves to activate numerous
intracellular signaling pathways via its interaction
with recept o r tyrosine kinases (RTKs). Gab1 is a
substrate of various RTKs, including EGFR, insulin recept
o r , cytokine recept o r s, a n d B cell antigen recept
o r s; a n d it acts as a docking protein f o r
several SH2-containing proteins (1-3). Tyrosine-phosph
o r ylated Gab1 may recruit cytosolic signaling proteins
to the cellular membrane, where they can act
on membrane-bound targets as well as activate
downstream pathways (4)
WB: 1:1,000
IP: 1:50
A. Western blot analysis on 293 cell lysate using
anti-Gab1 RabMAb (cat. #1626-1), dilution: 1:5,000.
B. Immunoflu o r escent staining of PC-12 cells
using anti-Gab-1 RabMAb (catalog #1626-1).