Quality Standard：【产品介绍】Gelsolin is a large a n d complex
actin-binding protein that belongs to
actin-severing gelsolin/villin super family. Gelsolin is
a regulat o r of actin filament assembly a n d disassembly
a n d consists of six homologous subdomains (S1-S6).
When C-terminal tail (S6) is bound to calcium ion,
it straightens a n d exposes actin binding sites located
on S2s helices, leading to Gelsolin actin-serving
activity (1). Gelsolin is inhibited by
phosphatidylinositol (4,5)-bisphosphate (PIP2), where
PIP2 will bind to S1, S2, a n d S3 sites. Gelsolin
is involved in podosome f o r mation a n d has been
linked to inhibition of apoptosis by preventing release
of cytochrome C (2).
WB: 1:1000 5000
IHC: 1:100-250
A. Western blot analysis on NIH 3T3 cell lysate
using anti-Gelsolin RabMAb (cat. #2097-1), 1:5000 dilution.
B. Immunohistochemical analysis of paraffin-embedded
human tonsils using anti-Gelsolin RabMAb (cat# 2097-1)
沪公网安备 31012002003055号