Quality Standard:【产品介绍】cIAP-2, also known as HIAP-1, is a member of
the inhibit o r of apoptosis (IAP) family of proteins.
These proteins contain a BIR (baculovirus IAP repeat)
domain near the amino-terminus (1). cIAP-2 is localized
to the cytoplasm. The BIR motifs region interacts with
TNF recept o r associated fact o r s 1 a n d 2 (TRAF1
a n d TRAF2) to f o r m a heteromeric complex, which is
then recruited to the tum o r necrosis fact o r recept o r
2 (TNFR2). This complex is thought to play a role
in inhibition of apoptosis (2,3). cIAP-2 inhibits
cytochrome c-induced activation of caspase-9,
thereby preventing initiation of the caspase cascade
a n d apoptosis (4).
WB: 1:500
IHC: 1:50
ICC: 1:100
IP: 1:50
A. Western blot analysis on Daudi cell lysate
using anti-HIAP-1/BIR3 RabMAb (catalog #1040-1),
dilution 1:1,000.
B. Immunohistochemical analysis of human n o r mal
spleen using anti-HIAP-1/BIR3 RabMAb (catalog #1040-1).