Quality Standard:【产品介绍】HNF4 (Hepatocyte Nuclear Factor 4) is a
nuclear receptor protein belonging to the steroid
hormone receptor superfamily. HNF4 is commonly expressed
in the liver and plays a critical role in liver
development by establishing and maintaining
hepatocyte differentiation (1). In human, two isoforms
of HNF4 exists, alpha and gamma. HNF4 alpha
is transcriptionally controlled transcription factor,
which binds to DNA sites required for the transcription
of alpha 1- antitrypsin, Apo CIII, transthyretin genes,
and HNF1 alpha (2). HNF4 alpha interacts with PGC-1
to activate gluconeogenesis, leading to
lipoprotein metabolism regulation (3). HNF4 alpha
defects are known to cause type I diabetes (4).
Recommended Applications
ICC
Applications and Recommended Dilution Factors
ICC: 1:50 - 100
Species Reactivity
Human
Products Data
Immunofluorescent staining of HepG2 cells using
anti-HNF-4 antibody conjugated with Dylight 488
(green, Cat# 4580-1) and Dapi (blue).
Specificity
A synthetic peptide corresponding to residues in human
HNF4 was used as an immunogen.