Quality Standard:【产品介绍】Antigen-specific cell contacts in the
immune system are strengthened by antigen-
nonspecific interactions, mediated in part by
lymphocyte-function associated (LFA) antigens.
Recently, ICAM-1 (intercellular adhesion molecule-1)
has been defined as a lig a n d f o r LFA-1.
Monoclonal antibodies to ICAM-1 block T lymphocyte
adhesion to fibroblasts a n d endothelial cells
a n d disrupt the interaction between cytotoxic T cells
a n d target cells. ICAM-1 is found on
leukocytes, fibroblasts, epithelial cells a n d
endothelial cells a n d its expression is regulated
by inflammat o r y cytokines (1). The n o r mal function
of human intercellular adhesion molecule-1 (ICAM-1) is
to provide adhesion between endothelial cells
a n d leukocytes after injury o r stress. However, ICAM-1
is also used as a recept o r by the maj o r group of
human rhinoviruses a n d is a catalyst f o r the
subsequent viral uncoating during cell entry (2).
Monoclonal antibodies recognize a 95 kDa cell
surface glycoprotein the maj o r human rhinovirus recept
o r , ICAM-1 (3).
WB: 1:2000
IHC: 1:50 100
ICC: 1:100 - 250
A. Western blot analysis on Raji cell lysate
using anti-ICAM-1 RabMAb (cat. # 1929-1), dilution 1:2000
B. Immunohistochemical staining of paraffin-embedded
human tonsils using anti-ICAM-1 RabMAb (cat. #1929-1).