Quality Standard:【产品介绍】Antigen-specific cell contacts in the
immune system are strengthened by antigen-
nonspecific interactions, mediated in part by
lymphocyte-function associated (LFA) antigens.
ICAM-1 (intercellular adhesion molecule-1) has been
defined as a ligand for LFA-1. Monoclonal antibodies
to ICAM-1 block T lymphocyte adhesion to fibroblasts
and endothelial cells; they disrupt the interaction
between cytotoxic T cells and target cells (1). The
normal function of human intercellular adhesion
molecule-1 (ICAM-1) is to provide adhesion
between endothelial cells and leukocytes after injury
or stress. However, ICAM-1 is also used as a receptor by
the major group of human rhinoviruses and is a catalyst
for the subsequent viral uncoating during cell entry
(2). ICAM-1 is found on leukocytes, fibroblasts,
epithelial cells and endothelial cells; its expression
is regulated by inflammatory cytokines (1).
Recommended Applications
FC
Applications and Recommended Dilution Factors
FC: 1:100
Species Reactivity
Human
Products Data
Flow cytometric analysis of Ramos cells using ICAM-1
RabMAb (DyLight® 488 conjugate, cat.# 4589-1) (red)
compared to a nonspecific negative control antibody (green).
Specificity
A recombinant protein corresponding to a fragment near
the C-terminus of human ICAM-1 was used as an immunogen.