IKBKB

Molecular Formula：

Molecular Weight：

Alias：
IKBKB antibody, FLJ33771 antibody, FLJ36218 antibody, FLJ38368 antibody, FLJ40509 antibody, IKK-beta antibody, IKK2 antibody, IKKB antibody, MGC131801 antibody, NFKBIKB antibody, Inhibitor of nuclear factor kappa-B kinase subunit beta antibody, Nuclear fa

Product order：

Name	Specifications	Packing	Price	Delivery
IKBKB		100ul	Inquiry	现货

Character：
【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR6043
【用途】WB , IHC , ICC
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】85kDa

Quality Standard：
【产品介绍】IKK-beta (I-Kappa-B kinase-beta) is a member
of the IKK complex which is composed of IKK-alpha,
IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation
of I-Kappa-B on a serine residue by the IKK complex
frees NF-kB from I-Kappa-B and marks it for degradation
via ubiquitination. IKK-beta has been shown to
activate NF-kB and phosphorylate IKB-alpha and beta
(3). Phosphorylation of 2 sites at the activation loop
of IKK-beta is essential for activation of IKK by TNF
and IL1. Once activated, IKK-beta autophosphorylates
which in turn decreases IKK activity and prevents
prolonged activation of the inflammatory response
(4). Additionally, IKK-beta activity can also be
regulated by MEKK-1 (5).

Recommended Applications
WB, IHC, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:50 - 100
Species Reactivity *
Human, Mouse, Rat
*Cross reactivity with mouse determined by western blot
and IHC.
Cross reactivity with rat determined by western blot only.

Products Data

Western blot analysis on (A) HeLa and (B) 293T cell
lysates using anti-IKK beta (IKBKB) RabMAb (cat. #3902-1).

Immunohistochemical analysis of paraffin-embedded
human cervix carcinoma tissue using anti-IKK beta
(IKBKB) RabMAb (cat. #3902-1).

Immunofluorescent staining of HeLa cells using anti-IKK
beta (IKBKB) RabMAb (cat. #3902-1).

Immunohistochemical analysis of paraffin-embedded
mouse kidney tissue using anti-IKK beta (IKBKB) RabMAb
(cat. #3902-1).

Specificity
A synthetic peptide corresponding to residues at
the N-terminus of human IKK beta was used as an immunogen.

Storage：
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.