Quality Standard:【产品介绍】Interleukin-22 (IL-22), an IL-10
family cytokine, is expressed in activated T cells,
Th1 cells and NK cells (1, 2). IL-22 induces expression
of various antimicrobial peptides such as β-defensins
in skin, respiratory, and digestive tissues, which
express IL-22R (1). It also mediates the crosstalk
between leukocytes and tissue epithelia because its
receptor is preferentially expressed on various
tissue epithelial cells. IL-22 is essential for host
defense against infections of extracellular pathogens,
such as bacteria and yeasts, by eliciting various
innate defensive mechanisms from tissue epithelial cells
and promoting wound-healing responses (2). Enhanced
IL-22 levels have been linked to various states
of immunoactivation as seen in the context of
infection, autoimmunity, and allergic disorders (3).
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000 (10 ng)
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis.
Products Data
Western blot analysis on 10 ng of IL-22 recombinant
protein using anti-IL-22 RabMAb (cat. #5117-1). Note:
the recombinant protein corresponds to a lower
molecular weight, 14 kDa.
Specificity
A synthetic peptide corresponding to residues in human
IL-22 was used as an immunogen.