JAK2

Molecular Formula：

Molecular Weight：

Alias：
JAK2 antibody, JTK10 antibody, Tyrosine-protein kinase JAK2 antibody, Janus kinase 2 antibody

Product order：

Name	Specifications	Packing	Price	Delivery
JAK2		100ul	Inquiry	现货

Character：
【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR108(2)
【用途】WB , ICC
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】130kDa

Quality Standard：
【产品介绍】JAK2 is a member of the Janus family
(JAK) tyrosine kinases involved in cytokine
receptor-mediated intracellular signal transduction (1).
The JAK family is constitutively associated with
cytokine receptors; upon ligand binding, JAK
phosphorylates the receptor. JAK also phosphorylates
the cytokine receptor on tyrosine (Tyr) residues that
serve as docking sites for cytoplasmic signal
transducers and activators of transcription (STAT)
proteins (2). Activated STATs translocate to the nucleus
to mediate gene transcription (1, 3). JAK2 is
activated after binding to the following
Interleukin receptors: specifically IL-3 and IL-23 (4).
It also plays a role in leptin signaling and control
of body weight (4). A chromosomal aberration involving
JAK2 is found in a form of pre-B acute myeloid leukemia (5).

Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000-10,000
ICC: 1:100 - 500
Species Reactivity
Human, Mouse, Rat
Products Data

Western blot analysis on (A) TF-1, (B) K562, (C) THP-1,
(D) Jurkat, (E) NIH/3T3, and (F) IM-9 cell lysates
using anti-JAK2 RabMAb (cat. # 2863-1).

Specificity
A synthetic peptide corresponding to residues on
the C-terminus in human JAK2 was used as an immunogen.

Storage：
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.