Quality Standard：【产品介绍】Jak3 is a member of the Janus family
tyrosine kinases (Jaks), whose function is to
transduce extracellular signals from cytokines
a n d interferons. Jaks associate with cytokine recept
o r s; upon lig a n d binding, Jaks phosph o r ylate
the recept o r . The phosph o r ylated recept o r s
are bound by SH2-containing proteins, one class of which
is the signal transducers a n d activat o r s
of transcription (STATs). Activated STATs translocate to
the nucleus to mediate gene transcription (1, 2). Jak3
is activated after binding to the gamma chain of
Interleukin recept o r s, specifically IL-2, IL-4,
IL-7, IL-9, a n d IL-15 recept o r s. Jak3 has
been implicated in mast cell-mediated
immediate hypersensitivity reactions, autoimmune dis
o r ders, a n d acute lymphoblastic leukemia. Jak3 inhibit
o r has shown clinical potential as a new class
of immunomodulat o r y agents with anti-leukemic
a n d immunosuppressive properties (3).
WB: 1:2000
A. Western blot using anti-Jak3 Rabbit Polyclonal
(cat. # 1752-1) on TF-1 cell lysate at 1:2000 dilution.
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