LDL Receptor (C-term) (LDLR)

Molecular Formula：

Molecular Weight：

Alias：
LDLR antibody, FH antibody, FHC antibody, LDLCQ2 antibody, Low-density lipoprotein receptor antibody, antibody

Product order：

Name	Specifications	Packing	Price	Delivery
LDL Receptor (C-term) (LDLR)		100ul	Inquiry	现货

Character：
【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EP1553Y
【用途】WB , IHC , ICC , FC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】140/160 (2 isoforms)

Quality Standard：
【产品介绍】The low density lipoprotein (LDL)
receptor system coordinates the metabolism of
cholesterol, an essential component of the plasma
membrane of all mammalian cells. Study of this system
has led to an enhanced understanding of the cellular
basis of cholesterol homeostasis. It has also brought
into focus an important mechanism of
metabolic regulation--the process of receptor-
mediated endocytosis (1). Data suggest that
the juxtamembranous region of the cytoplasmic
domain participates in protein:protein interactions
that allow the low density lipoprotein receptor to
cluster in coated pits (2). It has been shown that
the family of LDL receptors may serve as viral
receptors. Endocytosis of the Flaviviridae
viruses, hepatitis C virus, GB virus C/hepatitis G
virus, and bovine viral diarrheal virus (BVDV) was shown
to be mediated by LDL receptors on cultured cells (3).

Recommended Applications
WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:1000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250
IP: 1:50
FC: 1:70
Species Reactivity *
Human, Mouse, Rat
*For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only

Products Data

A. Western blot analysis on HepG2 cell lysate using
anti-LDL receptor RabMAb (cat. # 1956-1), dilution 1:5000.

B. Immunohistochemical staining of paraffin-embedded
human liver using anti-LDLR RabMAb (cat. #1956-1).

C. Immunofluorescent staining of HEPG2 cells using
anti-LDLR RabMAb (cat. #1956-1).

Specificity
A synthetic peptide corresponding to residues on
the C-terminus of human LDL receptor was used as
an immunogen. This antibody detects both isoforms of
LDL receptor.

Storage：
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.