Quality Standard:【产品介绍】LIN28A, a promoter of pluripotency, is
a developmentally regulated RNA binding protein,
which selectively blocks the processing of pri-let-7
miRNAs in embryonic cells (1,2). One of the let-7
family members, let-7g targets and represses LIN28
through four 3'-UTR binding sites. It has been reported
that LIN28/let-7 pair has the potential to act as
a 'toggle switch' that balances the decision to
maintain pluripotency vs. differentiation (3). LIN28
was identified as a negative regulator of miRNA
biogenesis and suggested that it may play a central role
in blocking miRNA-mediated differentiation in stem cells
and in certain cancers (1).
Recommended Applications
ICC
Applications and Recommended Dilution Factors
ICC: 1:50 - 100
Species Reactivity
Human
Products Data
Immunofluorescent analysis of NCCIT cells using
LIN28A RabMAb (DyLight 594 conjugate, cat.# 4585-1)
(red) and Dapi (blue).
Specificity
A synthetic peptide corresponding to residues in
human LIN28A was used as an immunogen.